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Renal hemodynamic effects of relaxin in humans

Lookup NU author(s): Dr Marie Smith


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Rat studies have convincingly demonstrated the essential role of the ovarian hormone relaxin in mediating gestational renal hemodynamic and osmoregulatory changes in that species. We describe a model in nonpregnant volunteers using exogenous hCG to stimulate the production and release of ovarian relaxin in order to assess renal hemodynamic responses. Women (n = 10) were serially studied ± hCG stimulation during menstrual cycles with measurement of inulin, PAH, and neutral dextran clearances (to determine glomerular filtration rate [GFR], renal plasma flow [RPF], and glomerular porosity, respectively). Controls were women without ovarian function (n = 6) and men (n = 10). GFR and RPF were increased in the luteal phase compared to the follicular phase (15.3% increase in GFR, P <0.005; 17.8% increase in RPF, P <0.05). In controls, GFR and RPF were not significantly different between study occasions. Although exogenous hCG did not stimulate relaxin secretion in women without ovarian function or in men, it did so in normal women, but not into the pregnancy range. In no group were renal hemodynamics augmented by administered hCG. In naturally occurring cycles, increased serum relaxin is associated with augmented renal hemodynamics. As luteal stimulation with hCG failed to yield pregnancy relaxin levels, the use of exogenous relaxin for human administration is needed to further elucidate the renal vasodilatory properties of relaxin. © 2005 New York Academy of Sciences.

Publication metadata

Author(s): Smith M, Davison J, Conrad K, Danielson L

Editor(s): Sherwood OD; Fields PA; Steinetz BG

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Annals of the New York Academy of Sciences

Year of Conference: 2004

Pages: 163-172

ISSN: 9781573314855

Publisher: Wiley


DOI: 10.1196/annals.1282.024

PubMed id: 15956702

Notes: Relaxin and Related Peptides: Fourth International Conference, Volume 1041

Library holdings: Search Newcastle University Library for this item

ISBN: 17496632