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Bioactive pseudo-C-nucleosides containing thiazole, thiazolidinone, and tetrazole rings

Lookup NU author(s): Dr Richard WilkinsORCiD


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The synthesis of new pseudo-C-nucleosides was accomplished starting from 3-O-benzyl-1,2-O-isopropylidene-α-D-ribo-pentodialdo-1,4-furanose, aiming to build thiazole, triazole, tetrazole, and thiazolidinone derivatives. The stereochemistry of the thiazolidinone epimers was confirmed by DFT/B3LYP calculations. The well-known diversity of biological activities exhibited by compounds with these heterocyclic moieties in their structure encouraged the investigation of the insecticidal activity against Musca domestica. The thiazole derivative was efficient as insecticide with LD50 = 6.7 ng/g, which is in the order of the LD50 values for pyrethroids on the same insect. All the compounds tested showed knockdown, mediated through action on the insect nervous system. The neuroactivity found in insects has motivated the evaluation of the inhibition of acetylcholinesterase and butyrylcholinesterase. The two thiazolidinone derivatives tested inhibited butyrylcholinesterase from human serum (36% and 22%), while inhibition of amphiphilic acetylcholinesterase from human erythrocytes at the same concentrations was found to be very low (5% and 8%). This selective activity may indicate potential application of these structures for amelioration of Alzheimer's disease. Copyright © Taylor & Francis, Inc.

Publication metadata

Author(s): Rauter AP, Padilha M, Figueiredo JA, Ismael MI, Justino J, Ferreira H, Ferreira MJ, Rajendran C, Wilkins R, Vaz PD, Calhorda MJ

Publication type: Article

Publication status: Published

Journal: Journal of Carbohydrate Chemistry

Year: 2005

Volume: 24

Issue: 3

Pages: 275-296

Print publication date: 01/04/2005

ISSN (print): 0732-8303

ISSN (electronic): 1532-2327

Publisher: Taylor & Francis


DOI: 10.1081/CAR-200060396


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