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The role of the left Brodmann's areas 44 and 45 in reading words and pseudowords

Lookup NU author(s): Dr Kai Alter


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In this functional magnetic resonance imaging (fMRI) study, we investigated the influence of two task (lexical decision, LDT; phonological decision, PDT) on activation in Broca's region (left Brodmann's areas [BA] 44 and 45) during the processing of visually presented words and pseudowords. Reaction times were longer for pseudowords than words in LDT but did not differ in PDT. By combining the fMRI data with cytoarchitectonic anatomical probability maps, we demonstrated that the left BA 44 and BA 45 were stronger activated for pseudowords than for words. Separate analyses for LDT and PDT revealed that the left BA 44 was activated in both tasks, whereas left BA 45 was only involved in LDT. The results are interpreted within a dual-route model of reading with the left BA 44 supporting grapheme-to-phoneme conversion and the left BA 45 being related to explicit lexical search. © 2005 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Heim S, Alter K, Ischebeck A, Amunts K, Eickhoff S, Mohlberg H, Zilles K, Von Cramon D, Friederici A

Publication type: Article

Publication status: Published

Journal: Cognitive Brain Research

Year: 2005

Volume: 25

Issue: 3

Pages: 982-993

Print publication date: 01/12/2005

ISSN (print): 0926-6410

ISSN (electronic): 1872-6348

Publisher: Elsevier BV


DOI: 10.1016/j.cogbrainres.2005.09.022

PubMed id: 16310346


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