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Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

Lookup NU author(s): Dr Luke Gaughan, Professor Craig Robson, Dr Stuart McCracken, Professor David Neal

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Abstract

Internalization of activated receptors regulates signaling, and endocytic adaptor proteins are well-characterized in clathrin-mediated uptake. One of these adaptor proteins, huntingtin interacting protein 1 (HIP1), induces cellular transformation and is overexpressed in some prostate cancers. We have discovered that HIP1 associates with the androgen receptor through a central coiled coil domain and is recruited to DNA response elements upon androgen stimulation. HIP1 is a novel androgen receptor regulator, I significantly repressing transcription when knocked down using a silencing RNA approach and activating transcription when overexpressed. We have also identified a functional nuclear localization signal at the COOH terminus of HIP1, which contributes to the nuclear translocation of the protein. In conclusion, we have discovered that HIP1 is a nucleocytoplasmic protein capable of associating with membranes and DNA response elements and regulating transcription. © The Rockefeller University Press.


Publication metadata

Author(s): Mills, I., Gaughan, L., Robson, C. N., Ross, T., McCracken, S. R. C., Kelly, J., Neal, D. E.

Publication type: Article

Publication status: Published

Journal: Journal of Cell Biology

Year: 2005

Volume: 170

Issue: 2

Pages: 191-200

ISSN (print): 0021-9525

ISSN (electronic): 1540-8140

URL: http://dx.doi.org/10.1083/jcb.200503106

DOI: 10.1083/jcb.200503106

PubMed id: 16027218


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