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Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia

Lookup NU author(s): Professor Alan ThomasORCiD, Dr Clive Ballard, Professor Rose Anne Kenny, Professor John O'Brien, Arthur Oakley, Professor Raj KalariaORCiD


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Objective: To examine the relationship of the anatomic distribution of amyloid deposition to focal and global cognitive dysfunction in different subtypes of dementia. Methods: We quantified AB40 and AB42 in the temporal lobe and entorhinal cortex and examined their relation[A-Z] [A-Z]. ship to cognitive functions in Alzheimer's disease (AD), vascular dementia (VaD) and dementia with Lewy bodies (DLB). Results: We found a correlation between memory impairment, but not global cognitive impairment, and amyloid load in these areas in AD and VaD but not in DLB. This relationship was stronger for AB42 and in the entorhinal cortex. Conclusion: The anatomic location of amyloid deposition is an important factor-specific factor in memory impairment in AD and VaD. Copyright © 2005 S. Karger AG.

Publication metadata

Author(s): Thomas A, Ballard C, Kenny RA, O'Brien J, Oakley A, Kalaria R

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2005

Volume: 19

Issue: 2-3

Pages: 57-60

Print publication date: 01/01/2005

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG


DOI: 10.1159/000082349

PubMed id: 15572872


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