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Lookup NU author(s): Professor Alan ThomasORCiD, Dr Clive Ballard, Professor Rose Anne Kenny, Professor John O'Brien, Arthur Oakley, Professor Raj KalariaORCiD
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Objective: To examine the relationship of the anatomic distribution of amyloid deposition to focal and global cognitive dysfunction in different subtypes of dementia. Methods: We quantified AB40 and AB42 in the temporal lobe and entorhinal cortex and examined their relation[A-Z] [A-Z]. ship to cognitive functions in Alzheimer's disease (AD), vascular dementia (VaD) and dementia with Lewy bodies (DLB). Results: We found a correlation between memory impairment, but not global cognitive impairment, and amyloid load in these areas in AD and VaD but not in DLB. This relationship was stronger for AB42 and in the entorhinal cortex. Conclusion: The anatomic location of amyloid deposition is an important factor-specific factor in memory impairment in AD and VaD. Copyright © 2005 S. Karger AG.
Author(s): Thomas A, Ballard C, Kenny RA, O'Brien J, Oakley A, Kalaria R
Publication type: Article
Publication status: Published
Journal: Dementia and Geriatric Cognitive Disorders
Year: 2005
Volume: 19
Issue: 2-3
Pages: 57-60
Print publication date: 01/01/2005
ISSN (print): 1420-8008
ISSN (electronic): 1421-9824
Publisher: S. Karger AG
URL: http://dx.doi.org/10.1159/000082349
DOI: 10.1159/000082349
PubMed id: 15572872
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