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Lookup NU author(s): Emeritus Professor Arthur Covington
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All analyzers with ion-selective electrodes for ionized magnesium (iMg) should yield comparable and unbiased results. The prerequisite to achieve this goal is to reach consensus on sampling, measurement and reporting. The recommended guidelines for sampling, measurement and reporting iMg in plasma ("plasma" refers to circulating plasma and the forms in which it is sampled: the plasma phase of anticoagulated whole blood, plasma separated from blood cells, or serum) or blood, referring to the substance concentration of iMg in the calibrants, will provide results for iMg that are approximately 3% greater than its true concentration, and 4% less than its true molality. Binding of magnesium to proteins and ligands in plasma and blood is pH-dependent. Therefore, pH should be simultaneously measured to allow adjustment of iMg concentration to pH 7.4. The substance concentration of iMg may be physiologically and consequently clinically more relevant than the substance concentration of total magnesium. © 2005 by Walter de Gruyter.
Author(s): Ben Rayana MC, Burnett RW, Covington AK, D'Orazio P, Fogh-Andersen N, Jacobs E, Kulpmann WR, Kuwa K, Larsson L, Lewenstam A, Maas AHJ, Mager G, Naskalski JHJ, Okorodudu AO, Ritter C, St John A
Publication type: Article
Publication status: Published
Journal: Clinical Chemistry and Laboratory Medicine
Year: 2005
Volume: 43
Issue: 5
Pages: 564-569
Print publication date: 01/05/2005
ISSN (print): 1434-6621
ISSN (electronic): 1437-4331
Publisher: Walter de Gruyter
URL: http://dx.doi.org/10.1515/CCLM.2005.098
DOI: 10.1515/CCLM.2005.098
PubMed id: 15899681
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