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White matter hyperintensities and depression - Preliminary results from the LADIS study

Lookup NU author(s): Dr Michael FirbankORCiD, Professor John O'Brien, Dr Sanjeet Pakrasi, Dr Timo Erkinjuntti


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Background: White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood. Methods: In a pan-European multicentre study of 629 older subjects, we examined the relationship between MRI white matter hyperintensities (WMH), depressive symptoms and self perceived health quality of life (QOL). WMH were rated using a three-point scale. Results: We found depressive symptoms as assessed by the geriatric depression 15-item scale to be associated with WMH rating (Spearman's rho 0.11, p=0.008) and also with the Euro-QOL health score (Spearman's rho -0.5, p<0.001). In a ordinal logistic regression model, QOL was found to strongly predict GDS score (p<0.001) and severe vs mild WMH were associated with increased depression (p=0.028). The relationship between history of severe depression and WMH score was examined, but there were no differences either between those with and without a history of severe depression, or those with an early vs late onset of depression. Conclusions: The results suggest that WMH play a role in increasing depressive symptoms, even when perceived quality of life is controlled for as a possible mediating factor. Copyright © 2005 John Wiley & Sons, Ltd.

Publication metadata

Author(s): Firbank MJ, O'Brien JT, Pakrasi S, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund L-O, van Straaten I, Inzitari D, Scheletens P, Barkhof F, Velderman AK, Nagy Z, May Z, Ovary C, Barsi P, Pataky I, Waldermar G, Garde E, Rostrup E, Ryberg C, Vogel A, Paulson O, Hejl AM, Jakobsen O, Klimkowicz A, Bosak M, Szwabowska D, Basile AM, Bartolini L, Salvatori E, Moretti M, Mascalchi M, Pracucci G, Trallori P, Jonsson M, Gustavsson K, Nordlund A, Rolstad S, Edman A, Lind K, Ekholm S, Ribbelin S, Fazekas F, Schmidt R, Trummer U, Ropele S, Petrovic K, Pihanen P, Pohjasvaaran T, Somerkoski M-M, Iiovonen E, Mantyla R, Ylikoski R, Crisby M, Ryden E, Amberla K, Bronge L, Pettersson A, Eidehall A, Bogousslavski J, Ghika J, Ferro J, Madureira S, Verdelho A, Garcia C, Morgado C, Hennerici M, Baezner H-J, Blahak C, Grass A, Fassbender K, Mielke O, Gaa J, Hirsch J, Behrens S, Wiarda Mr, Minnett T, Harrison P, Gholkar A, Chanriat H, Benoist L, Hernandez K

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2005

Volume: 20

Issue: 7

Pages: 674-679

Print publication date: 01/07/2005

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: Wiley-Blackwell


DOI: 10.1002/gps.1342

PubMed id: 16021663


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