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Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

Lookup NU author(s): Dr Angela Pyle, Emeritus Professor Robert Perry, Professor David Burn, Professor Patrick Chinnery

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Abstract

There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or die UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases. © 2005 American Neurological Association Published by Wiley-Liss, Inc.

Publication metadata

Author(s): Pyle A, Foltynie T, Tiangyou W, Lambert C, Keers SM, Allcock LM, Davison J, Lewis SJ, Perry RH, Barker R, Burn DJ, Chinnery PF

Publication type: Article

Publication status: Published

Journal: Annals of Neurology

Year: 2005

Volume: 57

Issue: 4

Pages: 564-567

Print publication date: 01/04/2005

ISSN (print): 0364-5134

ISSN (electronic): 1531-8249

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1002/ana.20417

DOI: 10.1002/ana.20417

PubMed id: 15786469

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