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Lookup NU author(s): Dr Angela Pyle,
Emeritus Professor Robert Perry,
Professor David Burn,
Professor Patrick Chinnery
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There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or die UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases. © 2005 American Neurological Association Published by Wiley-Liss, Inc.
Author(s): Pyle A, Foltynie T, Tiangyou W, Lambert C, Keers SM, Allcock LM, Davison J, Lewis SJ, Perry RH, Barker R, Burn DJ, Chinnery PF
Publication type: Article
Publication status: Published
Journal: Annals of Neurology
Print publication date: 01/04/2005
ISSN (print): 0364-5134
ISSN (electronic): 1531-8249
PubMed id: 15786469
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