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Impact of hypertension and apolipoprotein E4 on poststroke cognition in subjects >75 years of age

Lookup NU author(s): Dr Elise Rowan, Dr Christopher Morris, Sally Stephens, Dr Clive Ballard, Dr Heather Dickinson, Dr Harpal Rao, Dr Brian Saxby, Dr Andrew McLaren, Professor Raj KalariaORCiD, Professor Rose Anne Kenny


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Background and Purpose - The apolipoprotein E4 allele (APOE4) associates with increased dementia risk, and hypertension may associate with mild cognitive deficits. We examined whether nondemented stroke patients with (1) a prestroke history of hypertension and (2) APOE4 were more cognitively impaired at 3 months after stroke. Methods - A total of 257 participants were genotyped and outcomes from neuropsychological evaluations analyzed using regression. Results - Total Cambridge Assessment for Mental Disorders in the Elderly (CAMCOG) and speed of working memory significantly associated with hypertension. No outcomes significantly associated with APOE4. Conclusions - Subjects with prestroke hypertension had more impaired global cognition and slower access to information held in working memory. © 2005 American Heart Association, Inc.

Publication metadata

Author(s): Rowan E, Morris CM, Stephens S, Ballard C, Dickinson H, Rao H, Saxby BK, McLaren AT, Kalaria RN, Kenny RA

Publication type: Article

Publication status: Published

Journal: Stroke

Year: 2005

Volume: 36

Issue: 9

Pages: 1864-1868

Print publication date: 28/07/2005

ISSN (print): 0039-2499

ISSN (electronic): 1524-4628

Publisher: Lippincott Williams & Wilkins


DOI: 10.1161/01.STR.0000177524.17424.2a

PubMed id: 16051894


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