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Lookup NU author(s): Dr Elise Rowan, Dr Christopher Morris, Sally Stephens, Dr Clive Ballard, Dr Heather Dickinson, Dr Harpal Rao, Dr Brian Saxby, Dr Andrew McLaren, Professor Raj KalariaORCiD, Professor Rose Anne Kenny
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Background and Purpose - The apolipoprotein E4 allele (APOE4) associates with increased dementia risk, and hypertension may associate with mild cognitive deficits. We examined whether nondemented stroke patients with (1) a prestroke history of hypertension and (2) APOE4 were more cognitively impaired at 3 months after stroke. Methods - A total of 257 participants were genotyped and outcomes from neuropsychological evaluations analyzed using regression. Results - Total Cambridge Assessment for Mental Disorders in the Elderly (CAMCOG) and speed of working memory significantly associated with hypertension. No outcomes significantly associated with APOE4. Conclusions - Subjects with prestroke hypertension had more impaired global cognition and slower access to information held in working memory. © 2005 American Heart Association, Inc.
Author(s): Rowan E, Morris CM, Stephens S, Ballard C, Dickinson H, Rao H, Saxby BK, McLaren AT, Kalaria RN, Kenny RA
Publication type: Article
Publication status: Published
Journal: Stroke
Year: 2005
Volume: 36
Issue: 9
Pages: 1864-1868
Print publication date: 28/07/2005
ISSN (print): 0039-2499
ISSN (electronic): 1524-4628
Publisher: Lippincott Williams & Wilkins
URL: http://dx.doi.org/10.1161/01.STR.0000177524.17424.2a
DOI: 10.1161/01.STR.0000177524.17424.2a
PubMed id: 16051894
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