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Lookup NU author(s): Dr Stuart Watson,
Emeritus Professor Nicol Ferrier,
Professor Allan Young
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Objective: To examine the hypothesis that hypothalamic-pituitary-adrenal (HPA) axis function is a trait abnormality in bipolar disorder. Method: We examined HPA axis function in a pilot study of five patients with rapid-cycling bipolar disorder in both relapse and remission using the dexamethasone/corticotropin releasing hormone (dex/CRH) test. Results: The cortisol response to the dex/CRH test correlated significantly between the 2 tests (r = 0.997; p < 0.0005). Conclusion: The data suggests that the cortisol response to the dex/CRH test is stable over time and independent of mood state.
Author(s): Watson S, Thompson JM, Malik N, Ferrier IN, Young AH
Publication type: Article
Publication status: Published
Journal: Australian and New Zealand Journal of Psychiatry
Print publication date: 01/04/2005
ISSN (print): 0004-8674
ISSN (electronic): 1440-1614
PubMed id: 15777360
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