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Factors predicting duration of delayed graft function in non-heart-beating donor kidney transplantation

Lookup NU author(s): John Asher, Professor Colin Wilson, Muhammed Gok, Professor Naeem Soomro, David Rix, Bryon Jaques, Professor Derek Manas, Dr Brian Shenton, David Talbot


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Non-heart-beating donors (NHBDs) are an important potential source of donor organs, but kidneys from such donors are prone to delayed graft function (DGF) and primary nonfunction, which are multifactorial in origin but believed to be mainly due to warm ischemic injury. This retrospective study examined a series of 88 transplants from Maastricht category II and III NHBDs to examine the role of factors to predict the duration of DGF. The main factors affecting duration of DGF were total warm ischemic time, cold ischemic time, product of perfusate GST concentration and donor age, quality of postoperative graft perfusion, incidence of acute rejection, recipient cardiovascular risk score, maximum pressure on machine perfusion, and weight gain during machine perfusion. Primary nonfunction was not accurately predicted from these factors for kidneys that had passed the viability assessment. © 2005 by Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Asher JF, Wilson CH, Gok MA, Balupuri S, Bhatti A, Soomro NA, Rix DA, Jaques BC, Manas DM, Shenton BK, Talbot D

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 20th International Congress of the Transplantion Society

Year of Conference: 2004

Pages: 348-349

ISSN: 0041-1345

Publisher: Transplantation Proceedings: Elsevier


DOI: 10.1016/j.transproceed.2004.11.036

PubMed id: 15808639