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Non-HLA immunogenetics in hematopoietic stem cell transplantation

Lookup NU author(s): Professor Anne Dickinson

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Abstract

Hematopoietic stem cell transplantation (HSCT) provides a unique environment in which to evaluate the role of immunogenetics of both the donor and the recipient to success of the procedure. The central role of HLA matching in HSCT has been established; however, recipients of allogeneic HSCT incur the risk of graft versus host disease (GVHD) even when the donor is a sibling who shares the major histocompatibility genes. Therefore, the perfect HLA match does not represent the optimal genetic make up. Other genetic systems operate and affect the various outcomes of HSCT, including GVHD, infections, transplant-related mortality, and overall survival. Minor histocompatibility antigens contribute to the control of GVHD as well as graft versus leukaemia reactions. In addition, genes controlling inflammatory processes, including cytokines, chemokines and their receptors, can modulate GVHD, and genes from both arms of the immune response (innate and adaptive) are strong candidates for susceptibility factors to infections in allogenic transplantation. © 2005 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Dickinson AM, Charron D

Publication type: Review

Publication status: Published

Journal: Current Opinion in Immunology

Year: 2005

Volume: 17

Issue: 5

Pages: 517-525

ISSN (print): 0952-7915

ISSN (electronic): 1879-0372

URL: http://dx.doi.org/10.1016/j.coi.2005.07.017

DOI: 10.1016/j.coi.2005.07.017

PubMed id: 16085403

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