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Low molecular weight polylactic acid as a matrix for the delayed release of pesticides

Lookup NU author(s): Jing Zhao, Dr Richard WilkinsORCiD


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Low molecular weight polylactic acid (LMW PLA) was used as a matrix to formulate biodegradable matrix granules and films with bromacil using a melt process. The compatibility of the PLA with bromacil was evaluated. The release characteristics of the formulations were investigated in vitro. The degradation and erosion of the formulations were monitored by pH and gravimetric analysis during the course of release. Various granules and films had similar biphasic release patterns, a delayed release followed by an explosive release. The release rates were independent of bromacil content in the matrix, but varied with the geometry of matrices. The mechanisms of diffusion and erosion were involved in the release. The delayed release of the formulations was dominantly governed by the degradation and erosion of PLA. LMW PLA underwent bulk erosion. LMW PLA-based matrix formulations could thus be useful for the application of pesticides to sensitive targets such as seed treatment. © 2005 American Chemical Society.

Publication metadata

Author(s): Zhao J, Wilkins RM

Publication type: Article

Publication status: Published

Journal: Journal of Agricultural and Food Chemistry

Year: 2005

Volume: 53

Issue: 10

Pages: 4076-4082

ISSN (print): 0021-8561

ISSN (electronic): 1520-5118

Publisher: American Chemical Society


DOI: 10.1021/jf0480400

PubMed id: 15884842


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