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Age-related differences in intracranial pressure and cerebral perfusion pressure in the first 6 hours of monitoring after children's head injury: Association with outcome

Lookup NU author(s): Dr Iain Chambers, Dr Lynne Stobbart, Dr Paul Jones, Emeritus Professor David Mendelow


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Objectives: Severe head injury in childhood is associated with considerable mortality and morbidity. In this study we determined age-related differences in the relationship between outcome and intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in the first 6 h of monitoring in a large cohort of head-injured children. Methods: Two hundred and thirty-five head-injured children (admitted to five UK hospitals over a 15-year period) in whom intracranial pressure monitoring was clinically indicated were studied. Results: Patients were divided into three age groups (2 - 6, 7 - 10 and 11 - 16 years). The sensitivity of ICP and CPP were similar. Differences were found in the specificity of ICP and CPP for each group and these were more marked for CPP. For a specificity of 50% the pressures were 53, 63 and 66 mmHg for the three age groups. Conclusions: There are age-related differences in the specificity of intracranial pressure and cerebral perfusion pressure in relation to outcome. These differences may be important in the clinical management of head-injured children. Thus cerebral perfusion pressures of 53, 63 and 66 mmHg should be the minimum to strive for in these three age groups respectively. © Springer-Verlag 2004.

Publication metadata

Author(s): Chambers IR, Stobbart L, Jones PA, Kirkham FJ, Marsh M, Mendelow AD, Minns RA, Struthers S, Tasker RC

Publication type: Article

Publication status: Published

Journal: Child's Nervous System

Year: 2005

Volume: 21

Issue: 3

Pages: 195-199

Print publication date: 01/03/2005

ISSN (print): 0256-7040

ISSN (electronic): 1433-0350

Publisher: Springer


DOI: 10.1007/s00381-004-1060-x

PubMed id: 15580513


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