Toggle Main Menu Toggle Search

Open Access padlockePrints

Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation

Lookup NU author(s): Elizabeth Sconce, Dr Tayyaba Khan, Dr Hilary Wynne, Professor Farhad Kamali

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Evidence suggests that alterations in the dietary intake of vitamin K can affect anticoagulation response to warfarin. It is possible that a low and erratic intake of dietary vitamin K is at least partly responsible for the variable response to warfarin in patients with unstable control of anticoagulation. Twenty-six patients with unstable and twenty-six with stable control of anticoagulation completed dietary records of all foods and drinks consumed on a daily basis for two consecutive weeks. The mean daily intake of vitamin K in unstable patients was considerably lower than that for stable patients during the study period (29±17μg v. 76±40μg). The logarithm of vitamin K intake was consistently and significantly lower in the unstable patients than the stable patients over the two week period (5.9±0.4μg v. 6.9±0.5μg; p<0.001; 95% CI: 0.7-1.2). Changes in vitamin K intake between weeks 1 and 2 of the study were negatively correlated with changes in International Normalised Ratio (INR) amongst the unstable patients, however this failed to reach significance (r=-0.25; p=0.22). Daily supplementation with oral vitamin K in unstable patients could lead to a more stable anticoagulation response to warfarin. © 2005 Schattauer GmbH, Stuttgart.


Publication metadata

Author(s): Sconce E, Khan T, Mason J, Noble F, Wynne H, Kamali F

Publication type: Article

Publication status: Published

Journal: Thrombosis and Haemostasis

Year: 2005

Volume: 93

Issue: 5

Pages: 872-875

Print publication date: 01/05/2005

ISSN (print): 0340-6245

ISSN (electronic): 0344-7618

Publisher: Schattauer GmbH

URL: http://dx.doi.org/10.1160/TH04-12-0773

DOI: 10.1160/TH04-12-0773

PubMed id: 15886802


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share