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Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation

Lookup NU author(s): Elizabeth Sconce, Dr Tayyaba Khan, Dr Hilary Wynne, Professor Farhad Kamali


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Evidence suggests that alterations in the dietary intake of vitamin K can affect anticoagulation response to warfarin. It is possible that a low and erratic intake of dietary vitamin K is at least partly responsible for the variable response to warfarin in patients with unstable control of anticoagulation. Twenty-six patients with unstable and twenty-six with stable control of anticoagulation completed dietary records of all foods and drinks consumed on a daily basis for two consecutive weeks. The mean daily intake of vitamin K in unstable patients was considerably lower than that for stable patients during the study period (29±17μg v. 76±40μg). The logarithm of vitamin K intake was consistently and significantly lower in the unstable patients than the stable patients over the two week period (5.9±0.4μg v. 6.9±0.5μg; p<0.001; 95% CI: 0.7-1.2). Changes in vitamin K intake between weeks 1 and 2 of the study were negatively correlated with changes in International Normalised Ratio (INR) amongst the unstable patients, however this failed to reach significance (r=-0.25; p=0.22). Daily supplementation with oral vitamin K in unstable patients could lead to a more stable anticoagulation response to warfarin. © 2005 Schattauer GmbH, Stuttgart.

Publication metadata

Author(s): Sconce E, Khan T, Mason J, Noble F, Wynne H, Kamali F

Publication type: Article

Publication status: Published

Journal: Thrombosis and Haemostasis

Year: 2005

Volume: 93

Issue: 5

Pages: 872-875

Print publication date: 01/05/2005

ISSN (print): 0340-6245

ISSN (electronic): 0344-7618

Publisher: Schattauer GmbH


DOI: 10.1160/TH04-12-0773

PubMed id: 15886802


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