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Long-term treatment with sub-antimicrobial dose doxycycline has no antibacterial effect on intestinal flora

Lookup NU author(s): Professor Philip Preshaw


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Aim: The purpose of this study was to determine if a 9-month regimen of sub-antimicrobial doxycycline (20 mg, bid) had an effect on either the intestinal or the vaginal microflora. Material and Methods: A total of 69 periodontally diseased subjects were randomized to receive drug or placebo control for a 9-month period. Stool specimens and vaginal swabs were collected at baseline and after 3 and 9 months of therapy. Samples were examined for total anaerobic counts, opportunistic pathogens, and doxycycline-resistant (≥4 μg/ml) bacteria. All isolates that survived sub-culture were identified and their susceptibilities determined to six antibiotics. Analyses were performed to determine if treatment differences were present. Results: The only statistically significant differences (p<0.05) between the two treatment groups occurred in the doxycycline-resistant counts at the baseline sample period for the faecal samples. This imbalance was before treatment initiation and the administration of the study drug. No between-treatment differences were detected at either the 3- or 9-month sample period either in the predominant bacterial taxa present or in their antibiotic susceptibilities. Conclusions: There was no evidence that sub-antimicrobial doxycycline treatment exerted an effect on the composition or doxycycline resistance level of either the faecal or the vaginal microflora. © Blackwell Munksgaard 2005.

Publication metadata

Author(s): Walker C, Preshaw PM, Novak J, Hefti AF, Bradshaw M, Powala C

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Periodontology

Year: 2005

Volume: 32

Issue: 11

Pages: 1163-1169

ISSN (print): 0303-6979

ISSN (electronic): 1600-051X

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/j.1600-051X.2005.00840.x

PubMed id: 16212578


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