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Lookup NU author(s): Professor Christopher Dennison
Type 1 (T1) copper sites promote biological electron transfer and are found in the cupredoxins and a number of copper-containing enzymes including the multi-copper oxidases. A T1 copper site usually has a distorted tetrahedral geometry with strong ligands provided by the thiolate sulfur of a Cys and the imidazole nitrogens of two His residues. The active site structure is typically completed by a weak axial Met ligand (a second weak axial interaction is found in azurin resulting in a trigonal bipyramidal geometry). The axial Met is not conserved and Gin, Phe, Leu and Val are also found in this position. Three of the four ligands at a T1 copper site are situated on a single C-terminal loop whose length and structure varies. Studies are discussed which investigate both the influence of physiologically relevant axial ligand alterations, and also of mutations to the length and structure of the ligand-containing loop, on the properties of T1 copper sites. © The Royal Society of Chemistry 2005.
Author(s): Dennison C
Publication type: Review
Publication status: Published
Journal: Dalton Transactions
Year: 2005
Issue: 21
Pages: 3436-3442
ISSN (print): 1477-9226
ISSN (electronic): 1477-9234
URL: http://dx.doi.org/10.1039/b507440c
DOI: 10.1039/b507440c
