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Functional status and quality of life in patients surviving 10 years after lung transplantation

Lookup NU author(s): Dr Robert Rutherford, Professor Andrew Fisher, Colin Hilton, Professor Kate Gould, Professor John Dark, Emeritus Professor Paul Corris


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Although many lung allograft recipients achieve long-term survival, there is a lack of published data regarding these patients' functional status and quality of life (QoL). We evaluated all 10-year survivors at our institution and, utilizing the SF-36 questionnaire, compared their QoL to population normative and chronic illness data. Twenty-eight (29%) of 96 patients survived ≥10 years following 11 single, 6 bilateral and 11 heart-lung procedures. At the most recent evaluation, median FEV1 in single and double lung recipients was predicted to be 54% and 74%, respectively. Five (18%) patients had BOS score 0, 13 (46%) BOS 1, 5 (18%) BOS 2 and 5 (18%) BOS 3 and median time to BOS was 7 years. Four (14%) patients required renal replacement therapy. Three patients (11%) developed symptomatic osteoporosis, 2 (7%) post-transplant lymphoma and 1 (4%) an ischaemic stroke. Scores for physical function, role-physical/emotional and general health, but not mental health and bodily pain, were significantly lower compared to normative and chronic illness data. Energy and social-function scores were significantly lower than normative data alone. Long-term survival after lung transplantation is characterized by an absence or delayed development of BOS, low iatrogenic morbidity and preserved mental, but reduced physical health status. Copyright © Blackwell Munksgaard 2005.

Publication metadata

Author(s): Rutherford RM, Fisher AJ, Hilton C, Forty J, Hasan A, Gould FK, Dark JH, Corris PA

Publication type: Article

Publication status: Published

Journal: American Journal of Transplantation

Year: 2005

Volume: 5

Issue: 5

Pages: 1099-1104

ISSN (print): 1600-6135

ISSN (electronic): 1600-6143

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/j.1600-6143.2004.00803.x

PubMed id: 15816892


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