Toggle Main Menu Toggle Search

Open Access padlockePrints

Carisolv™: An alternative to NaOCl in immature root canals?

Lookup NU author(s): Professor John Whitworth


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Aim: To test the null hypothesis that Carisolv™ is no more effective than 1% sodium hypochlorite in cleaning uninstrumented, immature root canals. Methodology: A total of 240 uniform, immature ovine incisors were decoronated at the CEJ level and randomly divided into four groups of 60. After gross pulp extirpation, canals were flooded with normal saline (negative control), 1% NaOCl, Carisolv™ or 5% NaOCl (positive control) and incubated for 10 min (group 1), 20 min (group 2), 30 min (group 3) or 30 min, refreshing irrigant at 10 and 20 min (group 4). SEM photomicrographs of canal wall debris in the apical, middle and coronal thirds were scored against a 5-point scale. Internal consistency was assessed by κ statistics. Debris scores for different irrigant regimes at different canal levels were analysed by non-parametric tests (P < 0.05). Results: Canals were consistently cleaner in the coronal and middle than apical thirds. NaOCl (5%) was consistently most effective. Carisolv™ and NaOCl (1%) were no more effective than normal saline in group 1 (P > 0.05), but significantly more effective than normal saline in groups 2 (middle and apical 1/3), 3 and 4 (P < 0.05). Carisolv and NaOCl (1%) had comparable activity in groups 1, 2 (middle and apical thirds) and 3, but NaOCl (1%) was significantly more effective than Carisolv in group 4 (coronal and middle thirds). Conclusions: 1. The ovine incisor model presents opportunities to investigate irrigation regimes under controlled ex-vivo conditions. 2. NaOCl (5%) remains the most effective irrigant for rapid debris removal in immature root canals. 3. Carisolv™ cleans pulp debris from the walls of immature root canals as effectively as NaOCl (1%) during static, unrefreshed wall contact for between 20 and 30 min. 4. Refreshment of NaOCl (1%) enhances its cleaning ability above that of Carisolv™. © 2005 International Endodontic Journal.

Publication metadata

Author(s): Rahman S, Whitworth JM, Dummer PMH

Publication type: Article

Publication status: Published

Journal: International Endodontic Journal

Year: 2005

Volume: 38

Issue: 7

Pages: 448-455

Print publication date: 01/07/2005

ISSN (print): 0143-2885

ISSN (electronic): 1365-2591

Publisher: Wiley


DOI: 10.1111/j.1365-2591.2005.00964.x

PubMed id: 15946265


Altmetrics provided by Altmetric


Find at Newcastle University icon    Link to this publication