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Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme

Lookup NU author(s): Dr Tevfik Dorak


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Associations of genetic factors with malignant gliomas have been modest. We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. For 155 glioblastoma multiforme patients and 157 control subjects closely matched by ethnicity, age, and gender, PCR-based techniques resolved alleles at HLA-A, -B, -C, and -DRB1 loci along with short tandem repeat polymorphisms of MICA exon 5 and TNFb. By multivariable logistic regression, B*13 and the B*07-Cw*07 haplotype were positively associated with glioblastoma multiforme (P = 0.01 and <0.001, respectively), whereas Cw*01 was the only variant showing a negative association (P = 0.05). Among glioblastoma multiforme patients, progression to death after diagnosis was slower in those with A*32 (relative hazard, 0.45; P < 0.01) and faster in those with B*55 (relative hazard, 2.27; P < 0.01). Thus, both the occurrence and the prognosis of glioblastoma multiforme could be associated with specific but different HLA genotypes. B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians. Copyright © 2005 American Association for Cancer Research.

Publication metadata

Author(s): Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS

Publication type: Article

Publication status: Published

Journal: Cancer Epidemiology Biomarkers and Prevention

Year: 2005

Volume: 14

Issue: 8

Pages: 2040-2044

ISSN (print): 1055-9965

ISSN (electronic): 1538-7755

Publisher: American Association for Cancer Research


DOI: 10.1158/1055-9965.EPI-05-0136

PubMed id: 16103458


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