Toggle Main Menu Toggle Search

Open Access padlockePrints

Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme

Lookup NU author(s): Dr Tevfik Dorak

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Associations of genetic factors with malignant gliomas have been modest. We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. For 155 glioblastoma multiforme patients and 157 control subjects closely matched by ethnicity, age, and gender, PCR-based techniques resolved alleles at HLA-A, -B, -C, and -DRB1 loci along with short tandem repeat polymorphisms of MICA exon 5 and TNFb. By multivariable logistic regression, B*13 and the B*07-Cw*07 haplotype were positively associated with glioblastoma multiforme (P = 0.01 and <0.001, respectively), whereas Cw*01 was the only variant showing a negative association (P = 0.05). Among glioblastoma multiforme patients, progression to death after diagnosis was slower in those with A*32 (relative hazard, 0.45; P < 0.01) and faster in those with B*55 (relative hazard, 2.27; P < 0.01). Thus, both the occurrence and the prognosis of glioblastoma multiforme could be associated with specific but different HLA genotypes. B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians. Copyright © 2005 American Association for Cancer Research.


Publication metadata

Author(s): Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS

Publication type: Article

Publication status: Published

Journal: Cancer Epidemiology Biomarkers and Prevention

Year: 2005

Volume: 14

Issue: 8

Pages: 2040-2044

ISSN (print): 1055-9965

ISSN (electronic): 1538-7755

Publisher: American Association for Cancer Research

URL: http://dx.doi.org/10.1158/1055-9965.EPI-05-0136

DOI: 10.1158/1055-9965.EPI-05-0136

PubMed id: 16103458


Altmetrics

Altmetrics provided by Altmetric


Share