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Familial neurocardiogenic (Vasovagal) syncope

Lookup NU author(s): Emerita Professor Julia Newton, Dr Simon Kerr, Jessie Pairman, Dr Andrew McLaren, Professor Rose Anne Kenny, Dr Christopher Morris


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Vasovagal syncope (VSS) is an exaggerated tendency towards the common faint caused by a sudden and profound hypotension with or without bradycardia. The etiology of VVS is unknown though several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Studies however indicate a strong heritable component to the etiology of VVS in over 20% of cases. Here, we report the findings from a family that shows apparently autosomal dominant VVS in at least three generations. Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members. © 2005 Wiley-Liss, Inc.

Publication metadata

Author(s): Newton JL, Kerr S, Pairman J, McLaren A, Norton M, Kenny RA, Morris CM

Publication type: Article

Publication status: Published

Journal: American Journal of Medical Genetics

Year: 2005

Volume: 133

Issue: 2

Pages: 176-179

ISSN (print): 1552-4825

ISSN (electronic): 1552-4833

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/ajmg.a.30572

PubMed id: 15666305


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