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Comparative genomics of trypanosomatid parasitic protozoa

Lookup NU author(s): Dr Cecilia Alsmark, Professor T. Martin Embley FMedSci FRS

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Abstract

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.


Publication metadata

Author(s): El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C, Ghedin E, Peacock C, Bartholomeu DC, Haas BJ, Tran A-N, Wortman JR, Alsmark UCM, Angiuoli S, Anupama A, Badger J, Bringaud F, Cadag E, Carlton JM, Cerqueira GC, Creasy T, Delcher AL, Djikeng A, Embley TM, Hauser C, Ivens AC, Kummerfeld SK, Pereira-Leal JB, Nilsson D, Peterson J, Salzberg SL, Shallom J, Silva JC, Sundaram J, Westenberger S, White O, Melville SE, Donelson JE, Andersson B, Stuart KD, Hall N

Publication type: Article

Publication status: Published

Journal: Science

Year: 2005

Volume: 309

Issue: 5733

Pages: 404-435

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science

URL: http://dx.doi.org/10.1126/science.1112181

DOI: 10.1126/science.1112181

PubMed id: 16020724


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Funding

Funder referenceFunder name
Wellcome Trust
AI45061NIAID NIH HHS
AI045039NIAID NIH HHS
AI45038NIAID NIH HHS
U01 AI045039NIAID NIH HHS
R01 AI043062NIAID NIH HHS
U01 AI040599NIAID NIH HHS
U01 AI043062NIAID NIH HHS
U01 AI045038NIAID NIH HHS

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