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Lookup NU author(s): Professor Simon ThomasORCiD
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Background: Insulin resistance is an independent risk factor for cardiovascular disease. The aim of this research was to establish the frequency of insulin resistance in a normoglycemic, hypertensive, male population to determine whether insulin resistance could be predicted by assessment of conventional risk factors and to assess the rate of deterioration. Methods: Insulin resistance was calculated in hypertensive patients and healthy control subjects using a homeostasis model assessment for insulin resistance (HOMA-IR) and was correlated with routinely measured clinical variables. Results: A total of 106 patients and 18 healthy control subjects were recruited. The healthy control subjects were similar to the patients in age and body mass index (BMI) but had a lower fasting glucose, insulin, and HOMA-IR. Of the patients, 36 were insulin sensitive (IS, HOMA-IR <1.5) and 21 were insulin resistant (IR, HOMA-IR >3.0). Mean blood pressure and type and number of antihypertensive medications did not differ between the groups. Compared with IS patients, IR patients were younger, had a higher BMI, higher triglycerides, and lower HDL, but there was substantial overlap of these risk factors between the groups. More IR than IS patients developed an impaired fasting glucose after 1 year (48% v 11%, P <. 001). After 3 years of follow-up, 10% of the IR group and none from the IS group were confirmed as having type 2 diabetes mellitus. Conclusions: In this study, insulin resistance was common (20%) and could not be reliably diagnosed using conventional risk factors. One-half of the IR patients developed an impaired fasting glucose by 1 year, and, of these individuals, 20% were confirmed as having type 2 diabetes mellitus by 3 years. © 2005 American Journal of Hypertension, Ltd.
Author(s): Mohteshamzadeh M, Wilkinson R, Thomas SHL
Publication type: Article
Publication status: Published
Journal: American Journal of Hypertension
Year: 2005
Volume: 18
Issue: 4
Pages: 452-456
ISSN (print): 0895-7061
ISSN (electronic): 1941-7225
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1016/j.amjhyper.2004.10.026
DOI: 10.1016/j.amjhyper.2004.10.026
PubMed id: 15831352
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