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Understanding how cells allocate metals using metal sensors and metallochaperones

Lookup NU author(s): Dr Stephen Tottey, Dr Duncan Harvie, Professor Nigel Robinson


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Each metalloprotein must somehow acquire the correct metal. We review the insights into metal specificity in cells provided by studies of ArsR-SmtB DNA binding, metal-responsive transcriptional repressors, and a bacterial copper chaperone. Cyanobacteria are the one bacterial group that have known enzymatic demand for cytoplasmic copper import. The copper chaperone and ATPases that supply cyanobacterial plastocyanin and cytochrome oxidase are reviewed, along with related ATPases for cobalt and zinc. These studies highlight the contributions of protein-protein interactions to metal speciation. Metal sensors and metallochaperones, along with metal transporters and metal-storage proteins, act in concert not only to supply the correct metals but also to withhold the wrong ones. © 2005 American Chemical Society.

Publication metadata

Author(s): Tottey S, Harvie DR, Robinson NJ

Publication type: Review

Publication status: Published

Journal: Accounts of Chemical Research

Year: 2005

Volume: 38

Issue: 10

Pages: 775-783

Print publication date: 01/10/2005

ISSN (print): 0001-4842

ISSN (electronic): 1520-4898


DOI: 10.1021/ar0300118

PubMed id: 16231873