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Asymmetric catalysis of carbon-carbon bond-forming reactions using metal(salen) complexes

Lookup NU author(s): Professor Michael North

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Abstract

The use of metal(salen) complexes in the asymmetric syntheses of cyanohydrins and amino acids have been developed as important and reliable methods of obtaining these highly versatile chiral intermediates. Thus, we have developed a number of titanium and vanadium(salen) complexes, with ligands derived from (R,R)-cyclohexane-1,2-diamine, which catalyze the synthesis of enantiomerically enriched O-protected cyanohydrins from various carbonyl compounds and cyanide sources. Nickel, copper and cobalt(salen) complexes have also been developed, as catalysts for the preparation of non-racemic amino acids under phase-transfer conditions. © Georg Thieme Verlag Stuttgart.

Publication metadata

Author(s): Achard TRJ, Clutterbuck LA, North M

Publication type: Article

Publication status: Published

Journal: Synlett

Year: 2005

Issue: 12

Pages: 1828-1847

Print publication date: 01/08/2005

ISSN (print): 0936-5214

ISSN (electronic): 1437-2096

Publisher: Georg Thieme Verlag

URL: http://dx.doi.org/10.1055/s-2005-871579

DOI: 10.1055/s-2005-871579

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