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Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers

Lookup NU author(s): Professor Mark Thomason, Emeritus Professor Robin Seymour, Professor Janice EllisORCiD


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Objectives: This study investigates the effect of a range of potential risk factors on the severity of gingival overgrowth in transplant patients medicated with ciclosporin in the absence of any calcium channel blockers. Materials and Methods: One hundred dentate solid organ transplants medicated with ciclosporin (but not calcium channel blockers or phenytoin) were recruited for the study. Demographic, pharmacological and periodontal data were recorded and gingival overgrowth assessed from stone models. Results: Univariate analysis identified the duration of transplant, papilla bleeding index, creatinine serum concentration, azathioprine and prednisolone dosage as risk factors for overgrowth severity. Multivariate modelling, excluding the periodontal parameters, gave a predictive model that included dosages of ciclosporin, azathioprine, prednisolone and weight (p < 0.0001, adjusted-R2 = 19%). Adding the periodontal variables strengthened the model (p < 0.0001, adjusted-R2 = 34.5%). Conclusion: The explanatory models in this study contain a number of variables that moderate inflammation (azathioprine and prednisolone) or are markers of it (papilla bleeding index). Dosage of each of the three immunosuppressants was identified as a risk factor for the severity of gingival change. This observation appears to have been masked by the effects of the calcium channel blockers in earlier studies. Copyright © Blackwell Munksgaard 2005.

Publication metadata

Author(s): Thomason JM, Seymour RA, Ellis JS

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Periodontology

Year: 2005

Volume: 32

Issue: 3

Pages: 273-279

Print publication date: 01/03/2005

ISSN (print): 0303-6979

ISSN (electronic): 1600-051X

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1600-051X.2005.00657.x

PubMed id: 15766370


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