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Lookup NU author(s): Dr Nicholas Allenby, Nicola O'Connor, Dr Zoltan Pragai, Emeritus Professor Alan Ward, Professor Anil Wipat, Professor Colin Harwood
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Bacillus subtilis responds to phosphate starvation stress by inducing the PhoP and SigB regulons. While the PhoP regulon provides a specific response to phosphate starvation stress, maximizing the acquisition of phosphate (P 1) from the environment and reducing the cellular requirement for this essential nutrient, the SigB regulon provides nonspecific resistance to stress by protecting essential cellular components, such as DNA and membranes. We have characterized the phosphate starvation stress response of B. subtilis at a genome-wide level using DNA macroarrays. A combination of outlier and cluster analyses identified putative new members of the PhoP regulon, namely, yfkN (2′,3′ cyclic nucleotide 2′-phosphodiesterase), yurI (RNase), yjdB (unknown), and vpr (extracellular serine protease). YurI is thought to be responsible for the nonspecific degradation of RNA, while the activity of YfkN on various nucleotide phosphates suggests that it could act on substrates liberated by YurI, which produces 3′ or 5′ phosphoribonucleotides. The putative new PhoP regulon members are either known or predicted to be secreted and are likely to be important for the recovery of inorganic phosphate from a variety of organic sources of phosphate in the environment. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Author(s): Allenby NEE, O'Connor N, Pragai Z, Ward AC, Wipat A, Harwood CR
Publication type: Article
Publication status: Published
Journal: Journal of Bacteriology
Year: 2005
Volume: 187
Issue: 23
Pages: 8063-8080
Print publication date: 01/12/2005
ISSN (print): 0021-9193
ISSN (electronic): 1067-8832
Publisher: American Society for Microbiology
URL: http://dx.doi.org/10.1128/JB.187.23.8063-8080.2005
DOI: 10.1128/JB.187.23.8063-8080.2005
PubMed id: 16291680
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