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Inhibition of root caries progression by an antibacterial adhesive

Lookup NU author(s): Professor Angus Walls


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A dentin primer containing the antibacterial monomer 12- methacryloyloxydodecylpyridinium bromide (MDPB) has been shown to penetrate and kill the bacteria in artificially demineralized dentin. We hypothesized that an experimental adhesive system, which incorporates the MDPB-containing primer, would be effective in inhibiting the progression of root caries in vitro. Artificial caries lesions were prepared by either an acid-gel or a Streptococcus mutans culture technique on the roots of extracted human teeth. The progression of these lesions after the application of the experimental or proprietary adhesive system was examined. Further demineralization was completely prevented by the experimental adhesive system, while lesions managed with the proprietary materials showed limited ability to inhibit further demineralization. We conclude that the experimental adhesive system can inhibit the progression of root-surface caries in vitro, through a combination of its antimicrobial activity and sealing of the demineralized dentin.

Publication metadata

Author(s): Kuramoto A, Imazato S, Walls AWG, Ebisu S

Publication type: Article

Publication status: Published

Journal: Journal of Dental Research

Year: 2005

Volume: 84

Issue: 1

Pages: 89-93

ISSN (print): 0022-0345

ISSN (electronic): 1544-0591

Publisher: Sage Publications, Inc.


DOI: 10.1177/154405910508400116

PubMed id: 15615883


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