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Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope

Lookup NU author(s): Emerita Professor Julia Newton, Dr Peter Donaldson, Dr Steve Parry, Professor Rose Anne Kenny, Dr Christopher Morris


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Recent studies suggest vasovagal syncope (VVS) has a significant heritable component (crude estimate sibling relative risk (λs): 1080) indicating that at least some forms of VVS may have a genetic cause. Here we present the first study examining a potential genetic abnormality in VVS. Methods: DNA was collected from consecutive patients attending our unit with head up tilt confirmed VVS (n = 165). One hundred and fourteen affected and unaffected first-degree relatives of those with a definitive diagnosis of VVS and positive family history also provided DNA. Results; DNA from 165 VVS index cases was genotyped for the ACE in sertion/deletion polymorphism. Mean ± SD age of cases was 56 ± 19 years (103 (62%) females). There was no significant difference in distribution of ACE insertion or deletion gene frequencies in cases compared with a large (>6000 subjects) national control population. No preferential transmission of alleles in families was identified using tests of association (P = 0.1789) Conclusion: We have shown using both a case control and a small family based association study that polymorphisms of ACE alone are not associated with increased risk of VVS. Further studies are planned to clarify the genotype/phenotype relationship in VVS and examine other candidate genes. © 2005 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Newton JL, Donaldson P, Parry S, Kenny RA, Smith J, Gibson AM, Morris C

Publication type: Article

Publication status: Published

Journal: Europace

Year: 2005

Volume: 7

Issue: 4

Pages: 396-399

Print publication date: 01/07/2005

ISSN (print): 1099-5129

ISSN (electronic): 1532-2092

Publisher: Oxford University Press


DOI: 10.1016/j.eupc.2005.03.001

PubMed id: 15944101


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