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Lookup NU author(s): Emerita Professor Anne Maguire, Dr Vida Zohoori, Professor John Mathers, Dr Nick Steen, Paul Hindmarch, Professor Paula Moynihan
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It has been suggested that systemic fluoride absorption from drinking water may be influenced by the type of fluoride compound in the water and by water hardness. Using a human double-blind cross-over trial, we conducted this study to measure cmax, Tmax, and Area Under the Curve (AUC) for plasma F concentration against time, following the ingestion of naturally fluoridated hard and soft waters, artificially fluoridated hard and soft waters, and a reference water. Mean AUC over 0 to 8 hours was 1330, 1440, 1679, 1566, and 1328 ng F.min.mL-1 for naturally fluoridated soft, naturally fluoridated hard, artificially fluoridated soft, artificially fluoridated hard, and reference waters, respectively, with no statistically significant differences among waters for AUC, cmax, or Tmax. Any differences in fluoride bioavailability between drinking waters in which fluoride is present naturally or added artificially, or the waters are hard or soft, were small compared with large within- and between-subject variations in F absorption.
Author(s): Maguire A, Zohouri FV, Mathers JC, Steen IN, Hindmarch PN, Moynihan PJ
Publication type: Article
Publication status: Published
Journal: Journal of Dental Research
Year: 2005
Volume: 84
Issue: 11
Pages: 989-993
Print publication date: 01/11/2005
ISSN (print): 0022-0345
ISSN (electronic): 1544-0591
Publisher: Sage
URL: http://dx.doi.org/10.1177/154405910508401104
DOI: 10.1177/154405910508401104
PubMed id: 16246928
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