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Bioavailability of fluoride in drinking water: A human experimental study

Lookup NU author(s): Emerita Professor Anne Maguire, Dr Vida Zohoori, Professor John Mathers, Dr Nick Steen, Paul Hindmarch, Professor Paula Moynihan


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It has been suggested that systemic fluoride absorption from drinking water may be influenced by the type of fluoride compound in the water and by water hardness. Using a human double-blind cross-over trial, we conducted this study to measure cmax, Tmax, and Area Under the Curve (AUC) for plasma F concentration against time, following the ingestion of naturally fluoridated hard and soft waters, artificially fluoridated hard and soft waters, and a reference water. Mean AUC over 0 to 8 hours was 1330, 1440, 1679, 1566, and 1328 ng F.min.mL-1 for naturally fluoridated soft, naturally fluoridated hard, artificially fluoridated soft, artificially fluoridated hard, and reference waters, respectively, with no statistically significant differences among waters for AUC, cmax, or Tmax. Any differences in fluoride bioavailability between drinking waters in which fluoride is present naturally or added artificially, or the waters are hard or soft, were small compared with large within- and between-subject variations in F absorption.

Publication metadata

Author(s): Maguire A, Zohouri FV, Mathers JC, Steen IN, Hindmarch PN, Moynihan PJ

Publication type: Article

Publication status: Published

Journal: Journal of Dental Research

Year: 2005

Volume: 84

Issue: 11

Pages: 989-993

Print publication date: 01/11/2005

ISSN (print): 0022-0345

ISSN (electronic): 1544-0591

Publisher: Sage


DOI: 10.1177/154405910508401104

PubMed id: 16246928


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