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Lookup NU author(s): Dr Ingrid Ehrmann,
Professor David Elliott
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Post-transcriptional mechanisms play an important role in the biology of germ cells, where they control key developmental decisions in cell division, differentiation and death. Because these post-transcriptional controls are cell-type-specific, and often utilize germ-cell-specific RNA-binding proteins, they provide useful diagnostic markers for male infertility and testicular cancer. Investigation of the genetics of male infertility in men and model organism suggests that disruption of post-transcriptional control mechanisms can cause specific germ cell pathologies, and these studies point to future possible therapeutic routes for restoring spermatogenesis.
Author(s): Ehrmann I, Elliott DJ
Publication type: Article
Publication status: Published
Journal: Reproductive BioMedicine Online
Print publication date: 10/05/2010
ISSN (print): 1472-6483
ISSN (electronic): 1472-6491
Publisher: Elsevier Ltd
PubMed id: 15705295
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