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Health status in patients with sub-clinical hypothyroidism

Lookup NU author(s): Dr Salman Razvi, Lorna Ingoe, Dr Jolanta Weaver


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Objective: Sub-clinical hypothyroidism (SCH) is a common disorder. People with this condition may have symptoms which could affect their perception of health. Therefore, the perceived health status of people with SCH was assessed and compared with population-matched norms. Design: A prospective cross-sectional survey. Methods: Seventy-one adults with SCH, age range 18-64 years were studied. Perceived health status was measured by the Short Form-36 (SF-36) version 2 questionaire, which has been validated in a UK population setting. The SF-36 has eight scales measuring physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional and mental health. Their SF-36 scores were compared with UK normative data after matching for age and sex and are reported as z-scores. Results: Scores of all eight SF-36 scales were significantly lower in people with SCH compared with the normative population. A negative score (compared with zero of the normative population) indicates worse health status. The most significantly impaired aspects of health status were vitality and role limitations due to physical problems (role physical scale) with z-scores (95% confidence intervals) of -1.01 (-0.74 to -1.29) and -0.73 (-0.43 to -1.04) respectively. Thyroid autoimmunity did not influence the results. Conclusion: Perceived health status is significantly impaired in people with SCH when compared with UK normative population scores. This needs to be taken into consideration by clinicians when managing patients with this disease. © 2005 Society of the European Journal of Endocrinology.

Publication metadata

Author(s): Razvi S, Ingoe LE, McMillan CV, Weaver JU

Publication type: Article

Publication status: Published

Journal: European Journal of Endocrinology

Year: 2005

Volume: 152

Issue: 5

Pages: 713-717

Print publication date: 01/05/2005

ISSN (print): 0804-4643

ISSN (electronic): 1479-683X

Publisher: BioScientifica Ltd.


DOI: 10.1530/eje.1.01907

PubMed id: 15879356


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