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Lookup NU author(s): Dr Trevor Jackson
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Centaurin β4 proteins are products of the DOEF1 (development and differentiation-enhancing factor 1) locus on human chromosome 8q24.1-24.2. Recent reports have indicated that this region and its products are amplified during development of several human cancers. Centaurins are GAPs (GTPase-activating proteins) that, together with GEFs (guanine nucleotide-exchange factors), regulate cyclic activation of Arts (ADP-ribosylation factors), members of the Ras GTPase superfamily. Centaurin β4 proteins associate with a variety of cellular signalling components implicated in control of growth, survival and movement and may act to direct assembly and/or disassembly of molecular complexes in concert with Art, lipid and protein phosphorylation signalling pathways. ©2005 Biochemical Society.
Author(s): Martin RK, Jackson TR
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 01/12/2005
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press
PubMed id: 16246099
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