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Centaurin β4 in cancer

Lookup NU author(s): Dr Trevor Jackson

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Abstract

Centaurin β4 proteins are products of the DOEF1 (development and differentiation-enhancing factor 1) locus on human chromosome 8q24.1-24.2. Recent reports have indicated that this region and its products are amplified during development of several human cancers. Centaurins are GAPs (GTPase-activating proteins) that, together with GEFs (guanine nucleotide-exchange factors), regulate cyclic activation of Arts (ADP-ribosylation factors), members of the Ras GTPase superfamily. Centaurin β4 proteins associate with a variety of cellular signalling components implicated in control of growth, survival and movement and may act to direct assembly and/or disassembly of molecular complexes in concert with Art, lipid and protein phosphorylation signalling pathways. ©2005 Biochemical Society.

Publication metadata

Author(s): Martin RK, Jackson TR

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2005

Volume: 33

Issue: 6

Pages: 1282-1284

Print publication date: 01/12/2005

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press

URL: http://dx.doi.org/10.1042/BST20051282

DOI: 10.1042/BST20051282

PubMed id: 16246099

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