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Biosensors: Basic features and application for fatty acid-binding protein, an early plasma marker of myocardial injury

Lookup NU author(s): Emeritus Professor Calum McNeilORCiD

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Abstract

Biosensors, especially immunosensors, are of great value for use in a clinical setting, since these are based on antigen-antibody reactions which are highly sensitive and specific. Furthermore, it becomes more and more important to measure specific compounds in biological matrices, such as blood or plasma, in a fast continuous manner. Biosensors are therefore suitable for application in high throughput systems. Until now only enzyme-biosensors have been developed for such systems. Continuous measurement of proteins could be established by use of the principle of displacement. This mini-review also presents the current status of biosensors for fatty acid-binding protein (FABP), a protein which is released very rapidly into the bloodstream after myocardial injury, and proven applicable as a plasma marker for acute myocardial injury. The various types of immunosensors for FABP are described, including a recently developed displacement sensor for this protein. The latter allows continuous measurement of FABP for future use in a bedside monitoring device. © 2004 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Van Der Voort D, McNeil CA, Renneberg R, Korf J, Hermens WT, Glatz JFC

Publication type: Article

Publication status: Published

Journal: Sensors and Actuators, B: Chemical

Year: 2005

Volume: 105

Issue: 1

Pages: 50-59

Print publication date: 14/02/2005

ISSN (print): 0925-4005

ISSN (electronic): 1873-3077

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.snb.2004.02.035

DOI: 10.1016/j.snb.2004.02.035

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