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Differential excitatory responses to oxytocin in sub-divisions of the bed nuclei of the stria terminalis

Lookup NU author(s): Professor Colin Ingram

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Abstract

The lateral dorsal nucleus of the bed nuclei of the stria terminalis (BST-LD) expresses dense oxytocin binding while lower binding is detected in the medial anterior BST (BST-MA) and adjacent ventrolateral septum (VLS). However, in vitro examination of neuronal responses to oxytocin showed that the BST-LD exhibited small, transient responses which desensitized upon repeated challenge. In contrast, the BST-MA and VLS exhibited significantly larger responses with no significant desensitization. This inverse relationship between oxytocin binding density and electrophysiological responsiveness is also seen in the central and medial amygdaloid nuclei, which have respective associations with the lateral and medial divisions of the BST. Thus, excitatory responses to oxytocin vary markedly between BST sub-divisions and may reflect associations within the extended amygdala. © 2005 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Wilson BC, Terenzi MG, Ingram CD

Publication type: Article

Publication status: Published

Journal: Neuropeptides

Year: 2005

Volume: 39

Issue: 4

Pages: 403-407

ISSN (print): 0143-4179

ISSN (electronic): 1532-2785

Publisher: Churchill Livingstone

URL: http://dx.doi.org/10.1016/j.npep.2005.04.001

DOI: 10.1016/j.npep.2005.04.001

PubMed id: 15975651

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