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Manganese superoxide dismutase in pathogenic fungi: An issue with pathophysiological and phylogenetic involvements

Lookup NU author(s): Dr Christophe Noel


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Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms. © 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Frealle E, Noel C, Viscogliosi E, Camus D, Dei-Cas E, Delhaes L

Publication type: Note

Publication status: Published

Journal: FEMS Immunology and Medical Microbiology

Year: 2005

Volume: 45

Issue: 3

Pages: 411-422

ISSN (print): 0928-8244

ISSN (electronic): 1574-695X


DOI: 10.1016/j.femsim.2005.06.003

PubMed id: 16055318