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Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes

Lookup NU author(s): Dr Balasubramanian Ravikumar, Dr Peter Carey, Dr David Cook, Dr R Neely, Dr Michael FirbankORCiD, Professor Roy Taylor


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Liver and skeletal muscle triglyceride stores are elevated in type 2 diabetes and correlate with insulin resistance. As postprandial handling of dietary fat may be a critical determinant of tissue triglyceride levels, we quantified postprandial fat storage in normal and type 2 diabetes subjects. Healthy volunteers (n = 8) and diet-controlled type 2 diabetes subjects (n = 12) were studied using a novel 13C magnetic resonance spectroscopy protocol to measure the postprandial increment in liver and skeletal muscle triglyceride following ingestion of 13C-labeled fatty acids given with a standard mixed meal. The postprandial increment in hepatic triglyceride was rapid in both groups (peak increment controls: +7.3 ± 1.5 mmol/1 at 6 h, P = 0.002; peak increment diabetics: +10.8 ± 3.4 mmol/1 at 4 h, P = 0.009). The mean postprandial incremental AUC of hepatic 13C enrichment between the first and second meals (0 and 4 h) was significantly higher in the diabetes group (6.1 ± 1.4 vs. 1.7 ± 0.6 mmol·1-1·h-1, P = 0.019). Postprandial increment in skeletal muscle triglyceride in the control group was small compared with the diabetic group, the mean 24-h postprandial incremental AUC being 0.2 ± 0.3 vs. 1.7 ± 0.4 mmol·1 -1·h-1 (P = 0.009). We conclude that the postprandial uptake of fatty acids by liver and skeletal muscle is increased in type 2 diabetes and may underlie the elevated tissue triglyceride stores and consequent insulin resistance. Copyright © 2005 the American Physiological Society.

Publication metadata

Author(s): Ravikumar B, Carey PE, Snaar JEM, Deelchand DK, Cook DB, Neely RDG, English PT, Firbank MJ, Morris PG, Taylor R

Publication type: Article

Publication status: Published

Journal: American Journal of Physiology: Endocrinology and Metabolism

Year: 2005

Volume: 288

Issue: 4

Pages: E789-E797

ISSN (print): 0193-1849

ISSN (electronic): 1522-1555

Publisher: American Physiological Society


DOI: 10.1152/ajpendo.00557.2004

PubMed id: 15572652


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