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Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies

Lookup NU author(s): Professor John O'Brien, Dr Michael FirbankORCiD, Dr Urs Mosimann, Professor David Burn, Professor Ian McKeith


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Fluctuations in consciousness and visual hallucinations are common neuropsychiatric features of dementia with Lewy bodies and Parkinson's disease dementia. To investigate potential neural correlates, we compared how changes in brain perfusion over a 1-year period were related to changes in the severity of these key clinical features. We recruited 29 subjects with either Parkinson's disease with dementia (15 subjects) or dementia with Lewy bodies (14 subjects). Cerebral perfusion was measured using HMPAO SPECT at baseline, and repeated 1 year later. The presence of hallucinations (Neuropsychiatric Inventory), severity of fluctuations in consciousness (fluctuation assessment scale) and cognitive ability (CAMCOG) were assessed at both time points. After controlling for changes in cognitive ability and effect of cholinesterase medication, we found a significant correlation between an increase in perfusion in midline posterior cingulate and decrease in hallucination severity. There was also a significant correlation between increased fluctuations of consciousness and increased thalamic and decreased inferior occipital perfusion. We have identified important neural correlates of key clinical features in Lewy body dementia and postulate that the associations can be understood through the influence of the cholinergic system on attention. © 2005 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): O'Brien JT, Firbank MJ, Mosimann UP, Burn DJ, McKeith IG

Publication type: Article

Publication status: Published

Journal: Psychiatry Research - Neuroimaging

Year: 2005

Volume: 139

Issue: 2

Pages: 79-88

ISSN (print): 0925-4927

ISSN (electronic): 1872-7506

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.pscychresns.2005.04.002

PubMed id: 15964748


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