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Mechanistic studies on synthetic Fe-S-Based clusters and their relevance to the action of nitrogenases

Lookup NU author(s): Professor Richard Henderson


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An overview is given of the mechanistic studies on synthetic Fe-S-based clusters and their relevance to the action of nitrogenases. Focus is on clusters with an Fe-S core which are widespread in biology, such that the mechanistic studies lead to greater understanding of the fundamental chemistry involved in the action of proteins containing such clusters. Topics covered include substitution reactions, protonation reactions, binding of substrate to clusters, transformation of substrates, mechanisms of the extracted FeMo-cofactor, and mechanisms of cluster assembly.

Publication metadata

Author(s): Henderson RA

Publication type: Review

Publication status: Published

Journal: Chemical Reviews

Year: 2005

Volume: 105

Issue: 6

Pages: 2365-2437

ISSN (print): 0009-2665

ISSN (electronic): 1520-6890


DOI: 10.1021/cr030706m

PubMed id: 15941217