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Enantiospecific formation of 3,6-dihydro-1H-pyridin-2-ones: Low-pressure palladium-catalysed decarboxylative carbonylation of 3-tosyl-5-vinyloxazolidin- 2-ones

Lookup NU author(s): Dr Julian Knight, Iain Lawson


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Palladium-catalysed decarboxylative carbonylation of 3-tosyl-5- vinyloxazolidin-2-ones 5 occurs at atmospheric pressure to give 1-tosyl-3,6-dihydro-1H-pyridin-2-ones 6. The reaction proceeds with no loss of enantiopurity and detosylation with sodium naphthalenide gives the title compounds in good yields. © Georg Thieme Verlag Stuttgart.

Publication metadata

Author(s): Knight JG, Lawson IM, Johnson CN

Publication type: Article

Publication status: Published

Journal: Synthesis

Year: 2006

Issue: 2

Pages: 227-230

ISSN (print): 0039-7881

ISSN (electronic): 1437-210X

Publisher: Georg Thieme Verlag


DOI: 10.1055/s-2005-924765


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