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Genetic progress towards the molecular basis of autoimmunity

Lookup NU author(s): Professor Simon Pearce

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Abstract

The past few years have seen the identification of PTPN22 and the confirmation of CTLA-4 as common autoimmune disease genes. Together with MHC and INS, these developments have increased the collection of confirmed susceptibility loci for autoimmunity. In this article, the latest developments related to these genes and to other recently studied candidate autoimmune susceptibility loci (PDCD1, FCRL3, SUMO4, CD25, PADI4 and SLC22A4) are reviewed. Collectively, these genes strongly indicate that aberrant inhibition of the signalling cascade initiated by activation of the T-cell receptor is involved in the aetiology of autoimmune disease. However, much basic genetic, molecular and clinical research is still needed to help us fully understand the underlying mechanisms of autoimmunity and how these translate into prognosis or therapy. © 2005 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Pearce SHS, Merriman TR

Publication type: Review

Publication status: Published

Journal: Trends in Molecular Medicine

Year: 2006

Volume: 12

Issue: 2

Pages: 90-98

ISSN (print): 1471-4914

ISSN (electronic): 1471-499X

URL: http://dx.doi.org/10.1016/j.molmed.2005.12.005

DOI: 10.1016/j.molmed.2005.12.005

PubMed id: 16412690


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