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A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children

Lookup NU author(s): Dr Katherine Wilson, Professor Nick Girdler


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The aim of the study was to compare oral midazolam and inhaled nitrous oxide as sedative agents during the management of children aged 5-10 years presenting for extraction of primary teeth under local anaesthetic. Subjects required two visits for the extraction of four primary teeth, one in each quadrant of the mouth, and were randomly allocated to be given nitrous oxide 30% in oxygen or oral midazolam 0.3 at the first visit, the other technique being used at the second visit. Vital signs, sedation levels and behavioural scores were recorded, and postoperative recall and satisfaction were reported by the patients. Thirty-five children, with a mean [range] age of 7.4 [5-10] years, completed the treatment. The mean dose of oral midazolam given was 8.6 [3.3-16.5] mg. The mean times taken to achieve the maximum level of sedation for midazolam and nitrous oxide sedation were 15.9 [2-30] min and 6.8 [2-10] min, respectively. Physiological parameters remained within acceptable clinical limits for both types of sedation. Oral midazolam was considered acceptable by 59% and was preferred by 36%. Oral midazolam sedation in 5 to 10-year-old children was shown to be as safe and effective as nitrous oxide in oxygen sedation for extraction of primary teeth but would not be the method of choice for all patients. © 2006 The Authors Journal compilation 2006 The Association of Anaesthetists of Great Britain and Ireland.

Publication metadata

Author(s): Wilson KE, Girdler NM, Welbury RR

Publication type: Article

Publication status: Published

Journal: Anaesthesia

Year: 2006

Volume: 61

Issue: 12

Pages: 1138-1144

ISSN (print): 0003-2409

ISSN (electronic): 1365-2044

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1365-2044.2006.04835.x

PubMed id: 17090232


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