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Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood

Lookup NU author(s): Emeritus Professor Arthur Covington

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Abstract

The proposed recommendation for measuring and reporting chloride in undiluted plasma† or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample. © 2006 by Walter de Gruyter.

Publication metadata

Author(s): Ben Rayana MC, Burnett RW, Covington AK, D'Orazio P, Fogh-Andersen N, Jacobs E, Kataky R, Kulpmann WR, Kuwa K, Larsson L, Lewenstam A, Maas AHJ, Mager G, Naskalski JW, Okorodudu AO, Ritter C, St John A

Publication type: Review

Publication status: Published

Journal: Clinical Chemistry and Laboratory Medicine

Year: 2006

Volume: 44

Issue: 3

Pages: 346-352

ISSN (print): 1434-6621

ISSN (electronic): 1437-4331

URL: http://dx.doi.org/10.1515/CCLM.2006.060

DOI: 10.1515/CCLM.2006.060

PubMed id: 16519610

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