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Estimation of optimal dynamic anticoagulation regimens from observational data: A regret-based approach

Lookup NU author(s): Professor Robin Henderson


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A complication of long-term anticoagulation is that the optimal dose level varies not only between patients but over time within patients, in response to short-term changes in lifestyle. Consequently, doseage needs to be adaptive but there are as yet no accepted decision rules. Since anticoagulant use is increasing worldwide there is a need for more objective and routine procedures. In this paper, we describe an analysis of observational longitudinal anticoagulant data, aimed at determining an optimal reactive dose-changing strategy. We use the regret parameterization approach advocated by Murphy (J. R. Stat. Soc. Ser. B 2003; 65:331-366). Practical problems encountered in the implementation of the approach are discussed and illustrated. Copyright © 2006 John Wiley & Sons, Ltd.

Publication metadata

Author(s): Rosthoj S, Fullwood C, Henderson R, Stewart S

Publication type: Article

Publication status: Published

Journal: Statistics in Medicine

Year: 2006

Volume: 25

Issue: 24

Pages: 4197-4215

ISSN (print): 0277-6715

ISSN (electronic): 1097-0258

Publisher: John Wiley & Sons Ltd.


DOI: 10.1002/sim.2694

PubMed id: 16981226


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Funder referenceFunder name
G0400615Medical Research Council
5R01 CA 54706-11NCI NIH HHS