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Human papillomavirus infection and cervical intraepithelial neoplasia in a cohort of low-risk women

Lookup NU author(s): Professor Louise Parker


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Objective: This study was a prospective examination of the incidence of human papillomavirus (HPV) infection in a low-risk female population and an assessment of the risk of development of LSIL with HPV infection. Study design: In a longitudinal study, women aged 19-60 years - non-smokers, and married or living with a constant partner, who presented for cervical cancer screening at an outpatient clinic - were invited to participate in a prospective study of cervical HPV infection, and were examined every 3 months. Results: Of the 464 women at risk, 20 presented with HPV infections during the follow-up. Low-grade squamous intraepithelial lesions (LSIL) event developed in 18 women. Among these women, 13 were HPV-positive (10 high-risk and 3 low-risk types). The average duration of new LSIL was 20.1 months (95% CI: 13.9-26.3) and 55.3 months (95% CI: 45.7-64.9) in the HPV-positive and negative groups, respectively, the difference was statistically significant (p < 0.001). With the use of Cox proportional hazard regression, we estimated the relative risk as 90.0 for a first instance of LSIL among women testing positive for HPV as compared with women testing negative for HPV. Conclusion: This study has provided evidence that HPV infection is associated with an increased risk of LSIL. © 2005 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Nyari T, Kalmar L, Nyari C, Parker L, Kovacs L, Thurzo L

Publication type: Article

Publication status: Published

Journal: European Journal of Obstetrics Gynecology and Reproductive Biology

Year: 2006

Volume: 126

Issue: 2

Pages: 246-249

ISSN (print): 0301-2115

ISSN (electronic): 1872-7654

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.ejogrb.2005.10.019

PubMed id: 16309820


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