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Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis

Lookup NU author(s): Professor Nick Reynolds, Dr Simon Meggitt

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Abstract

In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P < .02 and P < .03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis. © 2006 by The American Society of Human Genetics. All rights reserved.


Publication metadata

Author(s): Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, Reynolds NJ, Meggitt SJ, Kere J, Wahlgren C-F, Pershagen G, Wickman M, Nordenskjold M, Kockum I, Bradley M

Publication type: Article

Publication status: Published

Journal: American Journal of Human Genetics

Year: 2006

Volume: 78

Issue: 6

Pages: 1060-1065

ISSN (print): 0002-9297

ISSN (electronic): 1537-6605

Publisher: Cell Press

URL: http://dx.doi.org/10.1086/504272

DOI: 10.1086/504272

PubMed id: 16685656


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