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Relaxin has a role in establishing a renal response in pregnancy

Lookup NU author(s): Dr Marie Smith, Professor Alison Murdoch, Emeritus Professor John Davison


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Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9) had serial measurements of renal function made during the first trimester of pregnancy by using 24-hour creatinine clearance (CrCl) and plasma osmolality (Posm). All pregnancies were associated with increasing CrCl and reduced Posm, but the change from baseline was significantly greater in the women with normal ovarian function, indicating that in contrast to the rodent model, other factors in addition to circulating relaxin contribute to gestational renal adaptation to human pregnancy. © 2006 American Society for Reproductive Medicine.

Publication metadata

Author(s): Smith MC, Murdoch AP, Danielson LA, Conrad KP, Davison JM

Publication type: Article

Publication status: Published

Journal: Fertility and Sterility

Year: 2006

Volume: 86

Issue: 1

Pages: 253-255

ISSN (print): 0015-0282

ISSN (electronic): 1556-5653

Publisher: Elsevier


DOI: 10.1016/j.fertnstert.2005.11.070

PubMed id: 16730722


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