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Fluostatins C-E, novel members of the fluostatin family produced by Streptomyces strain acta 1383

Lookup NU author(s): Stefanie Baur, Amanda Jones, Professor Michael Goodfellow, Emeritus Professor Alan Ward

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Abstract

Three new members of the fluostatin family, fluostatins C-E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines. © Japan Antibiotics Research Association.

Publication metadata

Author(s): Baur S, Niehaus J, Karagouni AD, Katsifas EA, Chalkou K, Meintanis C, Jones AL, Goodfellow M, Ward AC, Beil W, Schneider K, Sussmuth RD, Fiedler H-P

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2006

Volume: 59

Issue: 5

Pages: 293-297

Print publication date: 01/05/2006

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ja.2006.41

DOI: 10.1038/ja.2006.41

PubMed id: 16883779

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