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Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes

Lookup NU author(s): Dr Alexandra Reis, Dr Suzanne Madgwick, Professor Keith Jones


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Separase not only triggers anaphase of meiosis I by proteolytic cleavage of cohesin on chromosome arms, but in vitro vertebrate separase also acts as a direct inhibitor of cyclin-dependent kinase 1 (Cdk1) on liberation from the inhibitory protein, securin. Blocking separase-Cdk1 complex formation by microinjection of anti-separase antibodies prevents polar-body extrusion in vertebrate oocytes. Importantly, proper meiotic maturation is rescued by chemical inhibition of Cdk1 or expression of Cdk1-binding separase fragments lacking cohesin-cleaving activity.

Publication metadata

Author(s): Gorr IH, Reis A, Boos D, Wuhr M, Madgwick S, Jones KT, Stemmann O

Publication type: Article

Publication status: Published

Journal: Nature Cell Biology

Year: 2006

Volume: 8

Issue: 9

Pages: 1035-1037

ISSN (print): 1465-7392

ISSN (electronic): 1476-4679

Publisher: Nature Publishing Group


DOI: 10.1038/ncb1467

PubMed id: 16906143


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Funder referenceFunder name
075744Wellcome Trust