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Pathophysiology of synuclein aggregation in Lewy body disease

Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska, Professor Ian McKeith


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We provide an overview of synaptic pathology in dementia with Lewy bodies (DLB) and related neurodegenerative disorders that are characterised by intraneuronal accumulation of α-synuclein aggregates. The review addresses the clinico-neuropathological correlates of synaptic pathology in Lewy body disease, and concentrates on: altered α-synuclein metabolism, mechanisms leading to α-synuclein fibril formation (self-polymerisation, α-synuclein mutations and post-translational modifications) and how these influence the axonal transport and synaptic network in ageing and disease process. Understanding the mechanisms leading to intraneuronal α-synuclein accumulation are crucial for the development of novel therapies for treatment of Lewy body disease. © 2005 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Mukaetova-Ladinska EB, McKeith IG

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2006

Volume: 127

Issue: 2

Pages: 188-202

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.mad.2005.09.014

PubMed id: 16297436


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Funder referenceFunder name
G0400074Medical Research Council