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Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska,
Professor Ian McKeith
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We provide an overview of synaptic pathology in dementia with Lewy bodies (DLB) and related neurodegenerative disorders that are characterised by intraneuronal accumulation of α-synuclein aggregates. The review addresses the clinico-neuropathological correlates of synaptic pathology in Lewy body disease, and concentrates on: altered α-synuclein metabolism, mechanisms leading to α-synuclein fibril formation (self-polymerisation, α-synuclein mutations and post-translational modifications) and how these influence the axonal transport and synaptic network in ageing and disease process. Understanding the mechanisms leading to intraneuronal α-synuclein accumulation are crucial for the development of novel therapies for treatment of Lewy body disease. © 2005 Elsevier Ireland Ltd. All rights reserved.
Author(s): Mukaetova-Ladinska EB, McKeith IG
Publication type: Article
Publication status: Published
Journal: Mechanisms of Ageing and Development
ISSN (print): 0047-6374
ISSN (electronic): 1872-6216
Publisher: Elsevier Ireland Ltd
PubMed id: 16297436
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